Thorne ZA503 | 5-Hydroxytryptophan (Formerly Griffonia) | 90 Capsules
5-Hydroxytryptophan (formerly Griffonia)
How to Use
Recommended Use or Purpose (Adults): Helps to promote healthy mood balance and used as a sleep aid. Use for a minimum of 1 week to see beneficial effects. Consult a health professional for use beyond one year. Recommended Dose (Adults): Take with food. To promote healthy mood balance: Take 1-2 capsules three times daily or as recommended by a health professional. To minimize the risk of gastrointestinal side effects, start dosing at 1 capsule three times daily and slowly increase to effective dose over a period of 2 weeks. For use as a sleep aid: Take 2-4 capsules daily or as recommended by a health professional. Take 30-45 minutes before bedtime.
5-Hydroxytryptophan (formerly Griffonia) Details
The serotonin levels in the body are associated with the regulation of sleep, mood, and appetite. A balanced serotonin level has been shown to support restful sleep, good mood, and decreased sugar cravings.* There are several ways to support a healthy serotonin level. L-tryptophan and 5-Hydroxytryptophan (5-HTP) are both precursors to serotonin. However, supplementation with 5-HTP is preferable, because unlike L-tryptophan, 5-HTP cannot be shunted into other uses in the body, such as niacin or protein production. 5-HTP is well absorbed by the body and easily crosses the blood-brain barrier where it can increase the synthesis of serotonin in the central nervous system.* And 5-HTP can be taken with meals without reducing its effectiveness.*
5-Hydroxytryptophan (5-HTP) is the intermediate metabolite the body produces when it initiates the process of converting the essential amino acid L-tryptophan to serotonin. Therefore, supplementation with 5-HTP will bypass the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase – which is the rate-limiting step in the synthesis of serotonin – and is a conversion that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.* 5-HTP is well absorbed when taken orally, with about 70 percent going into the bloodstream.* Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and its absorption is not affected by the presence of other amino acids; therefore, 5-HTP can be taken with meals without reducing its effectiveness. 5-HTP has been shown to have a beneficial impact on mood, sleep, carbohydrate cravings, and discomfort associated with fatigue.* Numerous studies of individuals with negative mood status have shown significant positive response with 50-300 mg of 5-HTP daily.*
To further facilitate serotonin production, Thorne’s 5-HTP formula contains pyridoxal 5′-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin. 5-HTP is commercially produced by extraction from the seeds of the African plant, Griffonia simplicifolia.
Each lot is thoroughly tested for contaminants, including Peak X, and is Peak X free.
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